Thanks to some chatter on a forum I have discovered Shaenon K. Garrity and Jeffrey Channing Wells's Skin Horse.
Its got a sci-fi theme, but is set in the sort-of present, and is about a team working for the government dealing with problems caused by genetically altered sentients.
The main team consist of a sentient swarm of bees, a rehabilitated Victorian criminal robot, an intelligent talking dog, and a zombie with love of large calibre guns and mayhem. But it's Tip, the new member and token human, that sold me on the strip.
Tip is a psychologist and a crossdresser. He's also got bags of confidence and is a hit with the ladies. Which makes a nice change.
Check out this recent strip after he seduces a Black Ops scientist (Click on the strip to embiggen):
I spent last night reading the archives. Its funny, clever, and sympathetic to nearly all the characters (even the opera-loving mutant silverfish in the basement!) Its so nice to see a positive portrayal of a tranny online too. Especially when its not the central theme of the comic, just a character detail.
The archives start here
4 days ago